Worst Vice President

A deeply offensive and fact free commentary on Fox News rates Biden as the worst VP ever and Harris as #2.  I'd put them close the opposite end of the spectrum

Really bad VPs, in no particular order:

Aaron Burr: Jefferson's VP in his first term.  Murdered Alexander Hamilton in a duel while serving as VP.  He was never tried for this, but Jefferson dropped him for his second term in favor of George Clinton.  Burr headed west and believing that war with Spain inevitable, provoked several incidents that came close to starting that war, specifically undermining Jefferson's careful policy.  Brought home and tried for treason and acquitted due to some shenanigans. 

Spiro Agnew: Nixon's VP for both terms.   Ran a bribetaking operation which started while he was governor of Maryland and continued when he was in the white house.   He pled Nolo Contendere to a single charge of tax evasion and resigned from office.  Apparently this was a deal: he never served a day in prison although he was disbarred and had to live the rest of his life on handouts from rich friends, most famously Frank Sinatra.

Richard Cheney: GW Bush's VP.  Manipulated and lied the country into two unnecessary and deeply counterproductive wars.  Advocated torture and suspension of due process.

John C Calhoun: VP for both Quincy Adams and Jackson. Believed that slavery was a positive good for the slaves themselves, strong proponent of states rights and nullification.  Probably bears more responsibility for the Civil War than any other individual, although he died in 1850.

John C Breckenridge: Buchanan's VP, he ran against Lincoln as the one fully pro-slavery candidate in the 1860 election.  After his defeat, he returned to the senate, but shortly joined the Confederate Army and was expelled at that time.

Andrew Johnson: Lincoln's VP in his second term.  He was inept and perpetually drunk, and undid many of the social gains from Civil War after Lincoln's assassination.  He was the first president to be impeached.

Pretty bad VPs:

Dan Quale.  George HW Bush's VP.  Obviously very stupid and inept, although it turns out not quite as incompetent as Pence

Mike Pence: Trump's VP.  Not as stridently stupid as Trump.

Chester Arthur: like many VPs, the only reason he was in office was as payment to corruptors.  When President Garfield was murdered, he proved so incompetent he wasn't able to do much, good or bad.

Calvin Coolidge: Harding's VP, he was not quite as corrupt as Harding himself, but pretty bad.  Like Arthur, he didn't really do much except allow the conditions that led to the Depression to fester.

My rankings put Burr and Cheney in a class by themselves, for actively and knowingly pursuing treasonous policies, along with many other evil that they did.  Calhoun and Breckenridge were traitors, but they they tried to work within the system to make it conform to their horrible ideas.

Trump would rank even on this list with Burr and Cheney for actively trying to overturn the lawful governance of the US, but he was never VP.